Methyl-CpG Binding Domain Protein 2 (MBD2) (Middle Region) Peptide
Quick Overview for Methyl-CpG Binding Domain Protein 2 (MBD2) (Middle Region) Peptide (ABIN8105271)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- MBD2 Peptide - middle region
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Sequence
- ARYLGNTVDL SSFDFRTGKM MPSKLQKNKQ RLRNDPLNQN KGKPDLNTTL
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- MBD2 Antibody (ARP87197_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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Background
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Background Information: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Symbols: DMTase, NY-CO-41
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Molecular Weight
- 33 kDa
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Gene ID
- 8932
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NCBI Accession
- NP_003918
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UniProt
- Q9UBB5
Target
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