MHC Class I Polypeptide-Related Sequence A (MICA) (Middle Region) Peptide
Quick Overview for MHC Class I Polypeptide-Related Sequence A (MICA) (Middle Region) Peptide (ABIN8105364)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- MICA Peptide - middle region
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Sequence
- QKEGLHSLQE IRVCEIHEDN STRSSQHFYY DGELFLSQNL ETKEWTMPQS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-MICA Antibody (ARP77876_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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Background
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Background Information: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Alternative Symbols: MIC-A, PERB11.1
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Molecular Weight
- 42 kDa
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Gene ID
- 100507436
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NCBI Accession
- NP_000238
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UniProt
- Q29983
Target
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