Minichromosome Maintenance Complex Component 3 (MCM3) Peptide
Quick Overview for Minichromosome Maintenance Complex Component 3 (MCM3) Peptide (ABIN8105429)
Target
Source
Application
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Purpose
- MCM3 Peptide
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-MCM3 antibody ( ARP36645_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))
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Background
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Background Information: MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Alternative Symbols: HCC5, MGC1157, P1-MCM3, P1.h, RLFB
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Molecular Weight
- 89kDa
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Gene ID
- 4172
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NCBI Accession
- NP_002379
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UniProt
- P25205
Target
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