Minichromosome Maintenance Deficient 4 (MCM4) Peptide
Quick Overview for Minichromosome Maintenance Deficient 4 (MCM4) Peptide (ABIN8105446)
Target
Source
Application
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Purpose
- MCM4 Peptide
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-MCM4 antibody ( ARP36649_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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Background
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Background Information: The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. The MCM4 gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.
Alternative Symbols: CDC21, CDC54, hCdc21, P1-CDC21
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Molecular Weight
- 95kDa
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Gene ID
- 4173
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NCBI Accession
- NP_005905
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UniProt
- P33991
Target
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