Neurofibromin 2 (NF2) (Middle Region) Peptide
Quick Overview for Neurofibromin 2 (NF2) (Middle Region) Peptide (ABIN8106345)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- NF2 Peptide - middle region
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Sequence
- QILDEKIYCP PEASVLLASY AVQAKYGDYD PSVHKRGFLA QEELLPKRVI
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- NF2 Antibody (ARP87349_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Merlin (NF2) (Neurofibromin 2 (NF2))
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Background
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Background Information: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Alternative Symbols: ACN, SCH, BANF
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Molecular Weight
- 28 kDa
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Gene ID
- 4771
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NCBI Accession
- NP_000259
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UniProt
- P35240
Target
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