Paired-Like Homeobox 2b (PHOX2B) (C-Term) Peptide
Quick Overview for Paired-Like Homeobox 2b (PHOX2B) (C-Term) Peptide (ABIN8107576)
Target
Origin
Source
Application
-
-
Protein Region
- C-Term
-
Purpose
- PHOX2B Peptide - C-terminal region
-
Sequence
- RAAAAAAAAA KNGSSGKKSD SSRDDESKEA KSTDPDSTGG PGPNPNPTPS
-
-
-
-
Application Notes
- Optimal working dilution should be determined by the investigator.
-
Comment
-
This is a synthetic peptide designed for use in combination with anti-PHX2B Antibody (ARP74127_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- PHOX2B (Paired-Like Homeobox 2b (PHOX2B))
-
Background
-
Background Information: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
Alternative Symbols: CCHS, PMX2B, NBLST2, NBPhox
-
Molecular Weight
- 34kDa
-
Gene ID
- 8929
-
NCBI Accession
- NP_003915
-
UniProt
- Q99453
Target
-
