Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) Peptide
Quick Overview for Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) Peptide (ABIN8107803)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- PIN1 Peptide - N-terminal region
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Sequence
- RPSGNSSSGG KNGQGEPARV RCSHLLVKHS QSRRPSSWRQ EKITRTKEEA
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Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) peptide
PIN1 Reactivity: Human, Rat, Mouse, Dog Host: Synthetic BP, Imm
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 22-255), (Extracellular Domain) peptidePIN1 Reactivity: Human Host: Escherichia coli (E. coli) SDS Dithiothreitol (DTT)
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-PIN1 Antibody (ARP63256_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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Background
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Background Information: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Alternative Symbols: DOD, UBL5
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Molecular Weight
- 18kDa
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Gene ID
- 5300
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NCBI Accession
- NP_006212
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UniProt
- Q13526
Target
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