Peptidylprolyl Isomerase D (PPID) (Middle Region) Peptide
Quick Overview for Peptidylprolyl Isomerase D (PPID) (Middle Region) Peptide (ABIN8107823)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- PPID Peptide - middle region
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Sequence
- GDDWGIFPKD GSGDSHPDFP EDADIDLKDV DKILLISEDL KNIGNTFFKS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- PPID Antibody (ARP90521_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- PPID (Peptidylprolyl Isomerase D (PPID))
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Background
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Background Information: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer, the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis.
Alternative Symbols: Ppif, Ppidl, CYP-40, 4930564J03Rik
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Molecular Weight
- 40 kDa
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Gene ID
- 67738
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NCBI Accession
- NP_080628
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UniProt
- Q9CR16
Target
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