Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (Middle Region) Peptide
Quick Overview for Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A) (Middle Region) Peptide (ABIN8108152)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- PLA2G4A Peptide - middle region
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Sequence
- SGSQSRGSTM EEELENITTK HIVSNDSSDS DDESHEPKGT ENEDAGSDYQ
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- PLA2G4A Antibody (ARP79178_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- PLA2G4A (Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) (PLA2G4A))
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Background
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Background Information: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants.
Alternative Symbols: cPLA2, PLA2G4, cPLA2-alpha
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Molecular Weight
- 82 kDa
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Gene ID
- 5321
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NCBI Accession
- NP_001298122
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UniProt
- P47712
Target
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