Poly A Specific Ribonuclease (PARN) (Middle Region) Peptide
Quick Overview for Poly A Specific Ribonuclease (PARN) (Middle Region) Peptide (ABIN8108453)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- PARN Peptide - middle region
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Sequence
- CQSSSIDFLA SQGFDFNKVF RNGIPYLNQE EERQLREQYD EKRSQANGAG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-PARN Antibody (ARP74700_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- PARN (Poly A Specific Ribonuclease (PARN))
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Background
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Background Information: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Symbols: DAN, DKCB6, PFBMFT4
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Molecular Weight
- 70 kDa
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Gene ID
- 5073
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NCBI Accession
- NP_001127949
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UniProt
- O95453
Target
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