Presenilin 2 (Alzheimer Disease 4) (PSEN2) (Middle Region) Peptide
Quick Overview for Presenilin 2 (Alzheimer Disease 4) (PSEN2) (Middle Region) Peptide (ABIN8108893)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- PSEN2 Peptide - middle region
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Sequence
- ALVFIKYLPE WSAWVILGAI SVYDLVAVLC PKGPLRMLVE TAQERNEPIF
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Presenilin 2 (Alzheimer Disease 4) (PSEN2) peptide
PSEN2 Host: Synthetic BP, WB, IHC
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- PSEN2 Antibody (ARP97209_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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Background
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Background Information: This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene.
Alternative Symbols: presenilin-2
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Molecular Weight
- 50 kDa
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Gene ID
- 19165
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NCBI Accession
- NP_001122077
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UniProt
- Q61144
Target
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