Pyrin and HIN Domain Family, Member 1 (PYHIN1) Peptide
Quick Overview for Pyrin and HIN Domain Family, Member 1 (PYHIN1) Peptide (ABIN8109720)
Target
Source
Application
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Purpose
- PYHIN1 Peptide
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-PYHIN1 antibody ( ARP50876_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))
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Background
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Background Information: PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Alternative Symbols: IFIX, MGC23885, RP11-520H16.1
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Molecular Weight
- 51kDa
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Gene ID
- 149628
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NCBI Accession
- NP_945148
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UniProt
- Q6K0P9
Target
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