Ras Homolog Gene Family, Member B (RHOB) (Middle Region) Peptide
Quick Overview for Ras Homolog Gene Family, Member B (RHOB) (Middle Region) Peptide (ABIN8110062)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- RHOB Peptide - middle region
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Sequence
- CPNVPIILVA NKKDLRSDEH VRTELARMKQ EPVRTDDGRA MAVRIQAYDY
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-RHOB Antibody(ARP54702_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- RHOB (Ras Homolog Gene Family, Member B (RHOB))
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Background
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Background Information: RHOB mediates apoptosis in neoplastically transformed cells after DNA damage.RHOB is not essential for development but affects cell adhesion and growth factor signaling in transformed cells.RHOB plays a negative role in tumorigenesis as deletion causes tumor formation. RHOB is involved in intracellular protein trafficking of a number of proteins.RHOB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.RHOB is also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Alternative Symbols: ARH6, ARHB, MST081, MSTP081, RHOH6
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Molecular Weight
- 22kDa
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Gene ID
- 388
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NCBI Accession
- NP_004031
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UniProt
- P62745
Target
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