Renalase, FAD-Dependent Amine Oxidase (RNLS) (Middle Region) Peptide
Quick Overview for Renalase, FAD-Dependent Amine Oxidase (RNLS) (Middle Region) Peptide (ABIN8110277)
Target
Origin
Source
Application
-
-
Protein Region
- Middle Region
-
Purpose
- Rnls Peptide - middle region
-
Sequence
- GMKIGVPWSC RYLSSHPCIC FISIDNKKRN IESSECGPSV VIQTTVPFGV
-
-
-
-
Application Notes
- Optimal working dilution should be determined by the investigator.
-
Comment
-
This is a synthetic peptide designed for use in combination with anti-Rnls Antibody (ARP59612_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Buffer
- Lyophilized powder
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
-
Background
-
Background Information: Rnls is a probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. It degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Alternative Symbols: 6530404N21Rik, AI452315, AW060440, C10orf59
-
Molecular Weight
- 33kDa
-
Gene ID
- 67795
-
NCBI Accession
- NP_001161290
-
UniProt
- A7RDN6
Target
-
