RuvB-Like 1 (E. Coli) (RUVBL1) Peptide
Quick Overview for RuvB-Like 1 (E. Coli) (RUVBL1) Peptide (ABIN8111060)
Target
Source
Application
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Purpose
- RUVBL1 Peptide
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-RUVBL1 antibody ( ARP32349_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
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Background
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Background Information: RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Alternative Symbols: ECP54, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49A, INO80H, PONTIN
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Molecular Weight
- 50kDa
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Gene ID
- 8607
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NCBI Accession
- NP_003698
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UniProt
- Q9Y265
Target
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