SPC25, NDC80 Kinetochore Complex Component, Homolog (SPC25) (C-Term) Peptide
Quick Overview for SPC25, NDC80 Kinetochore Complex Component, Homolog (SPC25) (C-Term) Peptide (ABIN8112563)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- SPC25 Peptide - C-terminal region
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Sequence
- PYMFSMSINE AKEYEVYDSS PHLECLAEFQ EKVRKTNNFS AFLANIRKAF
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- SPC25 Antibody (ARP90654_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- SPC25 (SPC25, NDC80 Kinetochore Complex Component, Homolog (SPC25))
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Background
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Background Information: This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants.
Alternative Symbols: Spbc25, 2600017H08Rik, 2610205L13Rik
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Molecular Weight
- 19 kDa
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Gene ID
- 66442
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NCBI Accession
- NP_001186052
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UniProt
- Q3UA16
Target
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