SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) Peptide
Quick Overview for SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) Peptide (ABIN8113069)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- Senp6 Peptide - C-terminal region
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Sequence
- LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-Senp6 Antibody (ARP50599_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
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Background
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Background Information: Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Alternative Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797
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Molecular Weight
- 127kDa
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Gene ID
- 215351
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NCBI Accession
- NP_666115
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UniProt
- Q6P7W0
Target
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