TEA Domain Family Member 2 (TEAD2) (N-Term) Peptide
Quick Overview for TEA Domain Family Member 2 (TEAD2) (N-Term) Peptide (ABIN8113591)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- TEAD2 Peptide - N-terminal region
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Sequence
- DGGGWTGSEE GSEEGTGGSE GVGGDGSPDA EGVWSPDIEQ SFQEALAIYP
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- TEAD2 Antibody (ARP90596_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- TEAD2 (TEA Domain Family Member 2 (TEAD2))
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Background
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Background Information: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Alternative Symbols: ETF, Etdf, TEF4, TEF-4, TEAD-2
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Molecular Weight
- 48 kDa
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Gene ID
- 21677
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NCBI Accession
- NP_001272427
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UniProt
- P48301
Target
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