Ubiquitin Interaction Motif Containing 1 (UIMC1) (Middle Region) Peptide
Quick Overview for Ubiquitin Interaction Motif Containing 1 (UIMC1) (Middle Region) Peptide (ABIN8115164)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- UIMC1 Peptide - middle region
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Sequence
- GEQASEKNEC ISEDMGDEDK EERQESRASD WHSKTKDFQE SSIKSLKEKL
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-UIMC1 Antibody (ARP75596_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
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Background
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Background Information: UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Alternative Symbols: UIMC1,RAP80, RXRIP110,
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Molecular Weight
- 79kDa
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Gene ID
- 51720
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UniProt
- Q96RL1
Target
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