Ubiquitin Specific Peptidase 10 (USP10) (C-Term) Peptide
Quick Overview for Ubiquitin Specific Peptidase 10 (USP10) (C-Term) Peptide (ABIN8115179)
Target
Origin
Source
Application
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Protein Region
- C-Term
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Purpose
- Usp10 Peptide - C-terminal region
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Sequence
- RDIRPGAAFE PTYIYRLLTV IKSSLSEKGR QEDAEEYLGF ILNGLHEEML
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-Usp10 Antibody (ARP59301_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
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Background
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Background Information: Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
Alternative Symbols: MGC124997
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Molecular Weight
- 87kDa
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Gene ID
- 307905
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NCBI Accession
- NP_001029318
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UniProt
- Q3KR59
Target
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