Unc-13 Homolog B (UNC13B) (Middle Region) Peptide
UNC13B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN8115449
$145.08
Plus shipping costs $50.00
100 μg
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Quick Overview for Unc-13 Homolog B (UNC13B) (Middle Region) Peptide (ABIN8115449)
Target
UNC13B
(Unc-13 Homolog B (UNC13B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Purpose
- UNC13B Peptide - middle region
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Sequence
- SYDLDYPERR AISPTSSSRY GSSCNVSQGS SQLSELDQYH EQDDDHRETD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- UNC13B (Unc-13 Homolog B (UNC13B))
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Background
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Background Information: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Alternative Symbols: UNC13, MUNC13, Unc13h2
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Molecular Weight
- 181 kDa
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Gene ID
- 10497
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NCBI Accession
- NP_006368
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UniProt
- O14795
Target
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