Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) (Middle Region) Peptide
Quick Overview for Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) (Middle Region) Peptide (ABIN8115481)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Purpose
- UCP1 Peptide - middle region
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Sequence
- RMQAQSHLHG IKPRYTGTYN AYRVIATTES LSTLWKGTTP NLMRNVIINC
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Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) peptide
UCP1 Reactivity: Human, Mouse, Dog, Rat Host: Synthetic BP, Imm
Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) (AA 288-303) peptide (Ovalbumin)UCP1 Reactivity: Human Host: Synthetic WB, Imm, SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti- UCP1 Antibody (ARP89108_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- UCP1 (Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1))
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Background
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Background Information: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
Alternative Symbols: Ucp, Slc25a7, AI385626
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Molecular Weight
- 33 kDa
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Gene ID
- 22227
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NCBI Accession
- NP_033489
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UniProt
- P12242
Target
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