zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptide
Quick Overview for zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptide (ABIN8116061)
Target
Origin
Source
Application
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Protein Region
- N-Term
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Purpose
- ZAP70 Peptide - N-terminal region
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Sequence
- MRKKQIDVAI KVLKQGTEKA DTEEMMREAQ IMHQLDNPYI VRLIGVCQAE
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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This is a synthetic peptide designed for use in combination with anti-ZAP70 Antibody (ARP61186_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Buffer
- Lyophilized powder
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
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Background
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Background Information: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Alternative Symbols: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
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Molecular Weight
- 34kDa
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Gene ID
- 7535
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NCBI Accession
- NP_997402
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UniProt
- P43403
Target
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