Insulin Induced Gene 1 (INSIG1) Peptide
INSIG1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN935998
Quick Overview for Insulin Induced Gene 1 (INSIG1) Peptide (ABIN935998)
Target
INSIG1
(Insulin Induced Gene 1 (INSIG1))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of INSIG1 antibody,
Alternative Names: INSIG1 control peptide, INSIG1 antibody Blocking Peptide, Anti-INSIG1 Blocking Peptide, Insulin Induced Gene 1 Blocking Peptide, MGC26273 Blocking Peptide, INSIG1, INSIG-1, INSIG 1, INSIG-1 Blocking Peptide, INSIG 1 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Background
- Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.
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Molecular Weight
- 25 kDa
Target
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