Insulin Induced Gene 1 (INSIG1) (Middle Region) Peptide
INSIG1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all INSIG1 products
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-INSIG1 antibody (Catalog #: ARP40161_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- Synonyms
- cl-6 Peptide, cl6 Peptide, CL-6 Peptide, CL6 Peptide, fb55a03 Peptide, fi35b10 Peptide, wu:fb55a03 Peptide, wu:fi35b10 Peptide, zgc:55439 Peptide, 1810013C12Rik Peptide, Insig-1 Peptide, INSIG-1 Peptide, insulin induced gene 1 Peptide, insulin induced gene 1 L homeolog Peptide, INSIG1 Peptide, insig1 Peptide, insig1.L Peptide, Insig1 Peptide
- Background
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: CL-6, MGC1405, CL6
Protein Interaction Partner: HMGCR,SCAP,SREBF2,FAF2,PGRMC1,SCAP,SCAP,SREBF2,Scap,VCP
Protein Size: 330 - Molecular Weight
- 36 kDa
- Gene ID
- 3638
- NCBI Accession
- NM_198336, NP_938150
- UniProt
- A4D2M9
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