Insulin Induced Gene 1 (INSIG1) (Middle Region) Peptide
INSIG1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all INSIG1 products
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-INSIG1 antibody (Catalog #: ARP40166_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- Synonyms
- cl-6 Peptide, cl6 Peptide, CL-6 Peptide, CL6 Peptide, fb55a03 Peptide, fi35b10 Peptide, wu:fb55a03 Peptide, wu:fi35b10 Peptide, zgc:55439 Peptide, 1810013C12Rik Peptide, Insig-1 Peptide, INSIG-1 Peptide, insulin induced gene 1 Peptide, insulin induced gene 1 L homeolog Peptide, INSIG1 Peptide, insig1 Peptide, insig1.L Peptide, Insig1 Peptide
- Background
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC26273, INSIG1
Protein Interaction Partner: SCAP,SREBF2,SCAP
Protein Size: 225 - Molecular Weight
- 25 kDa
- Gene ID
- 51141
- NCBI Accession
- NM_016133, NP_057217
- UniProt
- Q9Y5U4
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