Insulin-Degrading Enzyme (IDE) Peptide
IDE
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN936344
Quick Overview for Insulin-Degrading Enzyme (IDE) Peptide (ABIN936344)
Target
IDE
(Insulin-Degrading Enzyme (IDE))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of IDE antibody,
Alternative Names: IDE control peptide, IDE antibody Blocking Peptide, Anti-IDE Blocking Peptide, insulin-degrading enzyme Blocking Peptide, FLJ35968 Blocking Peptide, INSULYSIN Blocking Peptide -
Purification
- Immunoaffinity chromatography
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- IDE (Insulin-Degrading Enzyme (IDE))
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Background
- This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
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Molecular Weight
- 118 kDa
Target
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