Insulin-Degrading Enzyme (IDE) (N-Term) Peptide
IDE
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all IDE products
- IDE (Insulin-Degrading Enzyme (IDE))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IDE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- IDE (Insulin-Degrading Enzyme (IDE))
- Synonyms
- zgc:162603 Peptide, IDE Peptide, 1300012G03Rik Peptide, 4833415K22Rik Peptide, AA675336 Peptide, AI507533 Peptide, INSDEGM Peptide, INSULYSIN Peptide, insulin degrading enzyme Peptide, insulin-degrading enzyme Peptide, metallopeptidase Peptide, IDE Peptide, ide Peptide, LOC591315 Peptide, CC1G_01115 Peptide, Bm1_26615 Peptide, PTRG_10875 Peptide, SJAG_01430 Peptide, EBI_21700 Peptide, VDBG_06702 Peptide, LOAG_08082 Peptide, PGTG_04982 Peptide, Tsp_00424 Peptide, Ide Peptide
- Background
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: APP,AR,IGF1,IGF2,INS,NR3C1,IGF1,IGF2,ZHX2
Protein Size: 1019 - Molecular Weight
- 118 kDa
- Gene ID
- 3416
- NCBI Accession
- NM_004969, NP_004960
- UniProt
- P14735
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