Presenilin 1 (PSEN1) Peptide
PSEN1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN937808
Quick Overview for Presenilin 1 (PSEN1) Peptide (ABIN937808)
Target
Presenilin 1 (PSEN1)
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of PSEN1 antibody,
Alternative Names: PSEN1 control peptide, PSEN1 antibody Blocking Peptide, Anti-PSEN1 Blocking Peptide, presenilin 1 Blocking Peptide, AD3 Blocking Peptide, FAD Blocking Peptide, PS1 Blocking Peptide, S182 Blocking Peptide, PSEN1, PSEN-1, PSEN 1, PSEN-1 Blocking Peptide, PSEN 1 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- Presenilin 1 (PSEN1)
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Background
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
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Molecular Weight
- 53 kDa
Target
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