Splicing Factor 3b, Subunit 3, 130kDa (SF3B3) Peptide
SF3B3
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN937843
Quick Overview for Splicing Factor 3b, Subunit 3, 130kDa (SF3B3) Peptide (ABIN937843)
Target
SF3B3
(Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- EHPPLCGRDH LSFRSYYFPV KNVIDGDLCE QFNSMEPNKQ KNVSEELDRT
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of SF3 B3 antibody,
Alternative Names: SF3B3 control peptide, SF3B3 antibody Blocking Peptide, Anti-SF3B3 Blocking Peptide, Splicing Factor 3B Subunit 3 130Kda Blocking Peptide, KIAA0017 Blocking Peptide, RSE1 Blocking Peptide, SAP130 Blocking Peptide, SF3b130 Blocking Peptide, STAF130 Blocking Peptide, SF3B3, SFB-3, SFB 3, SFB-3 Blocking Peptide, SFB 3 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))
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Background
- SF3B3 is subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
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Molecular Weight
- 135 kDa
Target
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