Splicing Factor 3b, Subunit 3, 130kDa (SF3B3) (Middle Region) Peptide
SF3B3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SF3B3 products
- SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TVAGADKFGN ICVVRLPPNT NDEVDEDPTG NKALWDRGLL NGASQKAEVI
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SF3B3 Antibody(ARP40730_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))
- Synonyms
- GB11574 Peptide, rse1 Peptide, sap130 Peptide, sf3b130 Peptide, staf130 Peptide, sf3b3 Peptide, 1810061H24Rik Peptide, 5730409A01Rik Peptide, AA409318 Peptide, D8Ertd633e Peptide, RSE1 Peptide, SAP130 Peptide, mKIAA0017 Peptide, ik:tdsubc_2b2 Peptide, wu:fb81f05 Peptide, xx:tdsubc_2b2 Peptide, zgc:55440 Peptide, SF3b130 Peptide, STAF130 Peptide, splicing factor 3b subunit 3 Peptide, splicing factor 3B subunit 3 Peptide, splicing factor 3b, subunit 3, 130kDa Peptide, splicing factor 3b subunit 3 L homeolog Peptide, splicing factor 3b, subunit 3 Peptide, SF3B3 Peptide, LOC550935 Peptide, sf3b3 Peptide, Sf3b3 Peptide, LOC100178056 Peptide, sf3b3.L Peptide
- Background
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SF3B3 is subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Alias Symbols: KIAA0017, RSE1, SAP130, SF3b130, STAF130
Protein Interaction Partner: HCK,MPP3,NOL12,SF3B1,SREK1,TAF9,YWHAG,APBB1,CFLAR,HGS,NCOR1,PRPF40A,RNPS1,RNU11,RNU12-2P,SF3A2,SF3B1,SF3B2,SMNDC1,SRRM1,SRRM2,SUPT3H,TAF9,TCEA1,TCERG1,TNFRSF10D,WBP4,WWOX,tat
Protein Size: 1217 - Molecular Weight
- 135 kDa
- Gene ID
- 23450
- NCBI Accession
- NM_012426, NP_036558
- UniProt
- Q15393
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