Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Peptide
TDP1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all TDP1 products
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- ETNVYLIGST PGRFQGSHRD NWGHFRLRKL LQAHAPSTPK GECWPIVGQF
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of Tdp1 antibody,
Alternative Names: Tdp1 control peptide, Tdp1 antibody Blocking Peptide, Anti-Tdp1 Blocking Peptide, tyrosyl-DNA phosphodiesterase 1 Blocking Peptide, 2810481F14Rik Blocking Peptide, 4921509N21Rik Blocking Peptide, AI838772 Blocking Peptide, AW493413 Blocking Peptide, E430034L06Rik Blocking Peptide, SCAN1 Blocking Peptide, Tdp1, Tdp-1, Tdp 1, Tdp-1 Blocking Peptide, Tdp 1 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
- Synonyms
- 2810481F14Rik Peptide, 4921509N21Rik Peptide, AI838772 Peptide, AW493413 Peptide, E430034L06Rik Peptide, MLZ-501 Peptide, SCAN1 Peptide, tdp1 Peptide, MGC83708 Peptide, TDP1 Peptide, F8M21.60 Peptide, F8M21_60 Peptide, tyrosyl-DNA phosphodiesterase 1 Peptide, tyrosyl-DNA phosphodiesterase 1 Peptide, tyrosyl-DNA Phosphodiesterase (Tdp1) Peptide, tyrosyl-DNA phosphodiesterase 1 L homeolog Peptide, tyrosyl-DNA phosphodiesterase-like protein Peptide, TDP1 Peptide, Tc00.1047053511191.10 Peptide, Tdp1 Peptide, tdp1.L Peptide, tdp1 Peptide, PTRG_11198 Peptide, MCYG_02121 Peptide, MGYG_03035 Peptide
- Background
- Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.
- Molecular Weight
- 64 kDa
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