2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) Peptide
OAS1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939056
Quick Overview for 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) Peptide (ABIN939056)
Target
OAS1
(2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- GWRQLAQEAE AWLNYPCFKN WDGSPVSSWI LLVRPPASSL PFIPAPLHEA
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of OAS1 antibody,
Alternative Names: OAS1 control peptide, OAS1 antibody Blocking Peptide, Anti-OAS1 Blocking Peptide, 2'5'-Oligoadenylate Synthetase 1 40/46Kda Blocking Peptide, IFI-4 Blocking Peptide, OIAS Blocking Peptide, OIASI Blocking Peptide, OAS1, OAS-1, OAS 1, OAS-1 Blocking Peptide, OAS 1 Blocking Peptide -
Purification
- Protein G affinity purified immunoglobulin
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
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Background
- OAS1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Mutations in this gene have been associated with host susceptibility to viral infection.
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Molecular Weight
- 42 kDa
Target
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