3-hydroxyanthranilate 3,4-Dioxygenase (HAAO) Peptide
HAAO
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939222
Quick Overview for 3-hydroxyanthranilate 3,4-Dioxygenase (HAAO) Peptide (ABIN939222)
Target
HAAO
(3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- HRDVVIRQGE IFLLPARVPH SPQRFANTVG LVVERRRLET ELDGLRYYVG
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of HAAO antibody,
Alternative Names: HAAO control peptide, HAAO antibody Blocking Peptide, Anti-HAAO Blocking Peptide, 3-Hydroxyanthranilate 34-Dioxygenase Blocking Peptide, 3-HAO Blocking Peptide, HAO Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
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Background
- 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders.
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Molecular Weight
- 32 kDa
Target
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