3-hydroxyanthranilate 3,4-Dioxygenase (HAAO) (N-Term) Peptide
HAAO
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HAAO products
- HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HAAO antibody (Catalog #: ARP42356_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
- Synonyms
- Afu2g17450 Peptide, 0610007K21Rik Peptide, 0610012J07Rik Peptide, 3-HAO Peptide, 3-HAOxase Peptide, 3HAO Peptide, zgc:103585 Peptide, HAO Peptide, 3-hydroxyanthranilate 3,4-dioxygenase Peptide, 3-hydroxyanthranilate 3,4-dioxygenase L homeolog Peptide, SPO1774 Peptide, CNB05620 Peptide, AFUA_2G17450 Peptide, Bcep18194_C7641 Peptide, Kfla_5491 Peptide, Micau_4935 Peptide, RBRH_03005 Peptide, Krodi_1278 Peptide, haao Peptide, HAAO Peptide, Haao Peptide, haao.L Peptide
- Background
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3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Alias Symbols: 3-HAO, HAO
Protein Interaction Partner: GAD1,GAD1
Protein Size: 286 - Molecular Weight
- 32 kDa
- Gene ID
- 23498
- NCBI Accession
- NM_012205, NP_036337
- UniProt
- P46952
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