E3 SUMO-Protein Ligase NSE2 (NSMCE2) Peptide
NSMCE2
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939758
Quick Overview for E3 SUMO-Protein Ligase NSE2 (NSMCE2) Peptide (ABIN939758)
Target
NSMCE2
(E3 SUMO-Protein Ligase NSE2 (NSMCE2))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- KFLALQSKNS DADFQNNEKF VQFKQQLKEL KKQCGLQADR EADGTEGVDE
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of NSMCE2 antibody,
Alternative Names: NSMCE2 control peptide, NSMCE2 antibody Blocking Peptide, Anti-NSMCE2 Blocking Peptide, Non-Smc Element 2 Mms21 Homolog Blocking Peptide, C8orf36 Blocking Peptide, FLJ32440 Blocking Peptide, MMS21 Blocking Peptide, NSE2 Blocking Peptide, NSMCE2, NSMCE-2, NSMCE 2, NSMCE-2 Blocking Peptide, NSMCE 2 Blocking Peptide -
Purification
- Immunoaffinity chromatography
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
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Background
- NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
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Molecular Weight
- 28 kDa
Target
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