E3 SUMO-Protein Ligase NSE2 (NSMCE2) (Middle Region) Peptide
NSMCE2
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all NSMCE2 products
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- Protein Region
- Middle Region
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NSMCE2 antibody (Catalog #: ARP55690_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- Synonyms
- 1110014D18Rik Peptide, AI661537 Peptide, RGD1305156 Peptide, C8orf36 Peptide, MMS21 Peptide, NSE2 Peptide, ZMIZ7 Peptide, Non-SMC element 2 Peptide, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Peptide, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog Peptide, Smc5-6 complex non-SMC subunit 2 Peptide, Nsmce2 Peptide, NSMCE2 Peptide, nsmce2.L Peptide, nse2 Peptide
- Background
-
NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Alias Symbols: C8orf36, FLJ32440, MMS21, NSE2
Protein Size: 247 - Molecular Weight
- 28 kDa
- Gene ID
- 286053
- NCBI Accession
- NM_173685, NP_775956
- UniProt
- Q96MF7
-
You are here:
