Suppressor of Cytokine Signaling 7 (SOCS7) Peptide
SOCS7
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all SOCS7 products
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- LDPKALPPGL ALERTWGPAA GLEAQLAALG LGQPAGPGVK TVGGGCCPCP
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of SOCS7 antibody,
Alternative Names: SOCS7 control peptide, SOCS7 antibody Blocking Peptide, Anti-SOCS7 Blocking Peptide, Suppressor Of Cytokine Signaling 7 Blocking Peptide, NAP4 Blocking Peptide, SOCS7, SOCS-7, SOCS 7, SOCS-7 Blocking Peptide, SOCS 7 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
- Synonyms
- NAP4 Peptide, NCKAP4 Peptide, SOCS4 Peptide, SOCS6 Peptide, 2310063P06Rik Peptide, C85125 Peptide, Nap4 Peptide, GB13951 Peptide, zgc:175115 Peptide, SOCS7 Peptide, socs7 Peptide, suppressor of cytokine signaling 7 Peptide, suppressor of cytokine signaling Peptide, SOCS7 Peptide, Socs7 Peptide, LOC413772 Peptide, socs7 Peptide
- Background
- SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- Molecular Weight
- 64 kDa
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