Actinin, alpha 4 (ACTN4) Peptide
ACTN4
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN972870
Quick Overview for Actinin, alpha 4 (ACTN4) Peptide (ABIN972870)
Target
alpha Actinin 4 (ACTN4)
(Actinin, alpha 4 (ACTN4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ACTN4 antibody (Catalog #: ARP42203_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
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Background
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Alpha actinins belong to the spectrin superfamily which is a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. ACTN4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in its gene have been associated with focal and segmental glomerulosclerosis.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Alias Symbols: DKFZp686K23158, FSGS, FSGS1, ACTININ-4
Protein Interaction Partner: CAMK2A,CAMK2B,LRRC7,PDLIM1,ACTC1,ACTN3,ADORA2A,ATP6V1B1,CAMK2A,CAMK2B,CAMK2G,COIL,COL17A1,GSN,ITGB1,LRRC7,MAGI1,MYOZ1,MYOZ2,NEB,NOS2,PDLIM1,PTPN11,PTPN6,SACS,SERPINE1,SLC2A4,SLC9A3R2,TJP1,TRIM3,USP6NL,CAMK2A,CAMK2B,COL17A1,GSN,INO80,Lrrc7,MAGI1,MYOZ1,MYOZ2,P2rx7,PDLIM1,SLC9A3R2,TRIM3,UBTF,USP6NL
Protein Size: 911 -
Molecular Weight
- 105 kDa
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Gene ID
- 81
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NCBI Accession
- NM_004924, NP_004915
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UniProt
- O43707
Target
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