Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (Middle Region) Peptide
ALS2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ALS2 products
- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ALRGMSDLPP YGSGSSVQRQ EPPISRSAKY TFYKDPRLKD ATYDGRWLSG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ALS2 Antibody(ARP57487_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
- Synonyms
- als2 Peptide, si:dkey-33m14.1 Peptide, ALS2CR6 Peptide, ALSJ Peptide, IAHSP Peptide, PLSJ Peptide, 3222402C23Rik Peptide, 9430073A21Rik Peptide, Als2cr6 Peptide, Alsin Peptide, mKIAA1563 Peptide, amyotrophic lateral sclerosis 2a (juvenile) Peptide, alsin Peptide, ALS2, alsin Rho guanine nucleotide exchange factor Peptide, amyotrophic lateral sclerosis 2 (juvenile) Peptide, als2a Peptide, CpipJ_CPIJ008258 Peptide, CpipJ_CPIJ008260 Peptide, ALS2 Peptide, Als2 Peptide
- Background
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The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ALS2CR6, ALSJ, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ
Protein Interaction Partner: YWHAB
Protein Size: 1657 - Molecular Weight
- 184 kDa
- Gene ID
- 57679
- NCBI Accession
- NM_020919, NP_065970
- UniProt
- Q96Q42
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