Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (Middle Region) Peptide
ALS2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973149
$160.46
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100 μg
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Quick Overview for Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (Middle Region) Peptide (ABIN973149)
Target
ALS2
(Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- ALRGMSDLPP YGSGSSVQRQ EPPISRSAKY TFYKDPRLKD ATYDGRWLSG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ALS2 Antibody(ARP57487_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
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Background
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The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ALS2CR6, ALSJ, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ
Protein Interaction Partner: YWHAB
Protein Size: 1657 -
Molecular Weight
- 184 kDa
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Gene ID
- 57679
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NCBI Accession
- NM_020919, NP_065970
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UniProt
- Q96Q42
Target
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