Androgen Receptor (AR) (N-Term) Peptide
AR
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Androgen Receptor (AR) products
- Androgen Receptor (AR)
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-AR antibody (Catalog #: ARP30974_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Androgen Receptor (AR) peptide
AR Reactivity: Human, Mouse, Rat, Cow, Dog, Pig Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Androgen Receptor (AR)
- Synonyms
- AIS Peptide, DHTR Peptide, HUMARA Peptide, HYSP1 Peptide, KD Peptide, NR3C4 Peptide, SBMA Peptide, SMAX1 Peptide, TFM Peptide, AW320017 Peptide, Tfm Peptide, Andr Peptide, AR Peptide, androgen receptor Peptide, AR Peptide, Ar Peptide, ar Peptide
- Background
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AR has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Alias Symbols: AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM, HYSP1
Protein Interaction Partner: AKT1,CASP1,CASP3,CASP7,CASP8,CAV1,FGF8,KLK2,KLK3,NCOA1,NCOA1,NCOA2,RB1,TGFB1I1,AES,AHR,AKT1,APOL2,APPBP2,AR,ATF2,BAG1,BRCA1,CALM1,CALR,CASP1,CASP3,CASP7,CASP8,CAV1,CCND1,CCNE1,CCNH,CDC25A,CDC25B,CDC37,CDK1,CDK6,CDK7,CDK9,COX5B,CREBBP,CTDSP2,CTNNB1,CUL4B,DAP3,DAXX,DCAF6,DDC,EFCAB6,EGFR,EP300,ESR1,ETV5,FHL2,FLNA,FOXA1,FOXO1,GAK,GAPDH,GNB2L1,GRIP1,GSK3B,GSN,GTF2F1,GTF2F2,GTF2H1,HDAC1,HIF1A,HIPK3,HMGB1,HSP90AA1,IARS,IDE,IFI16,IL6ST,JMJD1C,JUN,KAT2B,KAT5,KDM1A,KIF1A,KLK2,MAPK1,MDM2,MED1,MED14,MYBBP1A,MYST2,NCOA1,NCOA2,NCOA3,NCOA4,NCOR1,NCOR2,NFKB1,NISCH,NONO,NR0B1,NR0B2,NR2C1,NR2C2,NR3C1,NR3C2,NR5A1,NRIP1,NSD1,PA2G4,PAK6,PIAS1,PIAS2,PIAS3,PIAS4,PNRC1,PNRC2,POU2F1,POU5F1,PRMT1,PSMC3IP,PTEN,PXN,RAC3,RAD54L2,RAD9A,RAF1,RAN,RANBP9,RB1,RBAK,RCHY1,RELA,RNASEL,RNF14,RNF4,RUNX1,RUNX2,SART3,SLC25A4,SMAD1,SMAD3,SMAD4,SP1,SPDEF,SRC,SRY,STAT3,STUB1,SUMO1,SVIL,TCF4,TGFB1I1,TGIF1,TMF1,TRIM24,TRIP4,TSG101,UBE2I,UBE3A,UXT,WIPI1,XRCC5,XRCC6,ZMIZ1,AES,AKT1,AR,BAG1,BRCA1,CALM1,CALR,CAV1,CCND1,CCNE1,CCNH,CDC25B,CDC37,CDK7,CDK9,CEBPA,CEBPB,COX5B,CREBBP,CTNNB1,DAP3,DAXX,DCC,EFCAB6,EGFR,ETV5,FHL2,FLNA,FOXA1,FOXO1,GAPDH,GNB2L1,GRIP1,GSK3A,GSK3B,GSN,GTF2F1,GTF2F2,GTF2H1,HDAC1,HDAC3,HDAC4,HMGB1,HMGB2,HNF4A,HSP90AA1,HSPA1A,HSPB2,IL6ST,JUN,KAT5,MAGEA11,MAPK1,MDM2,MED1,MYST2,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOR1,NCOR2,NONO,NR0B1,NR0B2,NR2C1,NR2C2,NSD1,PA2G4,PAK6,PATZ1,PELP1,PIAS1,PIAS2,PIAS3,PIAS4,PMEPA1,POU2F1,POU2F2,PRKDC,PRMT1,PRPF6,PSPC1,PTEN,RAD9A,RAF1,RAN,RANBP9,RB1,RCHY1,RNF14,RNF4,SART3,SELENBP1,SMAD3,SMAD4,SMARCA4,SMARCC1,SP1,SPDEF,SRC,SRY,STAT3,SVIL,TBP,TCF4,TDG,TGFB1I1,TMF1,TP53,TRIM24,TRIM68,TSG101,UBC,UBE2I,UXT,XRCC5,XRCC6,YWHAQ,ZMIZ1
Protein Size: 920 - Molecular Weight
- 99 kDa
- Gene ID
- 367
- NCBI Accession
- NM_000044, NP_000035
- UniProt
- P10275
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