beta-Site APP-Cleaving Enzyme 2 (BACE2) (Middle Region) Peptide
BACE2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973703
Quick Overview for beta-Site APP-Cleaving Enzyme 2 (BACE2) (Middle Region) Peptide (ABIN973703)
Target
BACE2
(beta-Site APP-Cleaving Enzyme 2 (BACE2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- SLNLDCREYN ADKAIVDSGT TLLRLPQKVF DAVVEAVARA SLIPEFSDGF
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BACE2 Antibody(ARP46852_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
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Background
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Protein Interaction Partner: APP,BACE2,GGA1,GGA2
Protein Size: 396 -
Molecular Weight
- 37 kDa
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Gene ID
- 25825
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NCBI Accession
- NM_138992, NP_620477
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UniProt
- Q9Y5Z0
Target
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