beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) Peptide
BACE2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all BACE2 products
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BACE2 Antibody(ARP46853_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- Synonyms
- AEPLC Peptide, ALP56 Peptide, ASP1 Peptide, ASP21 Peptide, BAE2 Peptide, CEAP1 Peptide, DRAP Peptide, 1110059C24Rik Peptide, AI850424 Peptide, ARP1 Peptide, CDA13 Peptide, beta-site APP-cleaving enzyme 2 Peptide, BACE2 Peptide, Bace2 Peptide
- Background
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Protein Interaction Partner: APP,BACE2,GGA1,GGA2
Protein Size: 396 - Molecular Weight
- 37 kDa
- Gene ID
- 25825
- NCBI Accession
- NM_138992, NP_620477
- UniProt
- Q9Y5Z0
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