Bleomycin Hydrolase (BLMH) (Middle Region) Peptide
BLMH
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973829
$160.46
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100 μg
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Quick Overview for Bleomycin Hydrolase (BLMH) (Middle Region) Peptide (ABIN973829)
Target
BLMH
(Bleomycin Hydrolase (BLMH))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BLMH antibody (Catalog #: ARP56106_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BLMH (Bleomycin Hydrolase (BLMH))
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Background
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The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BH, BMH
Protein Interaction Partner: APP,BLMH,KBTBD7,RPL11,RPL29,TRIO,UBE2I,APP,BLMH,KBTBD7,RPL11,RPL29,TRIO,UBE2I,USP53
Protein Size: 455 -
Molecular Weight
- 52 kDa
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Gene ID
- 642
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NCBI Accession
- NM_000386, NP_000377
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UniProt
- Q13867
Target
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