Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (Middle Region) Peptide
CASP10
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Caspase 10 (CASP10) products
- Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HNNVTKVEME MVLQKQKCNP AHADGDCFVF CILTHGRFGA VYSSDEALIP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CASP10 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))
- Synonyms
- xCaspase-10 Peptide, alps2 Peptide, caspace-10 Peptide, caspase-10 Peptide, flice2 Peptide, mch4 Peptide, xCaspace-10 Peptide, ALPS2 Peptide, FLICE2 Peptide, MCH4 Peptide, caspase 10 S homeolog Peptide, caspase 10 Peptide, caspase-10 Peptide, casp10.S Peptide, casp10 Peptide, CASP10 Peptide, Casp10 Peptide, LOC100848685 Peptide
- Background
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: ALPS2, FLICE2, MCH4
Protein Interaction Partner: RB1,BFAR,BID,CASP10,CASP14,CASP2,CASP3,CASP4,CASP6,CASP7,CASP8,CASP9,CCAR1,CFLAR,DEDD,DEDD2,DSP,FADD,POLR2A,RB1,RYBP,TNFRSF1A,TRAF1,AIF1,ARHGDIA,BID,CASP1,CASP10,CASP14,CASP2,CASP3,CASP4,CASP6,CASP7,CASP8,CASP9,CFLAR,DEDD,DEDD2,EZR,FADD,FAS,FASLG,MAP3K14,
Protein Size: 479 - Molecular Weight
- 12 kDa
- Gene ID
- 843
- NCBI Accession
- NM_001230, NP_001221
- UniProt
- Q92851
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