Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (Middle Region) Peptide
CASP5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974476
$160.46
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100 μg
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Quick Overview for Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (Middle Region) Peptide (ABIN974476)
Target
CASP5
(Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VIIVQACRGE KHGELWVRDS PASLALISSQ SSENLEADSV CKIHEEKDFI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CASP5 Antibody(ARP58992_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
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Background
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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Alias Symbols: ICE(rel)III, ICEREL-III, ICH-3, MGC141966
Protein Interaction Partner: CASP5,MAX,NLRP1,PPHLN1,PPHLN1
Protein Size: 376 -
Molecular Weight
- 43 kDa
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Gene ID
- 838
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NCBI Accession
- NM_001136109, NP_001129581
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UniProt
- P51878
Target
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