CDC45 Cell Division Cycle 45 (CDC45L) (C-Term) Peptide
CDC45L
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974737
Quick Overview for CDC45 Cell Division Cycle 45 (CDC45L) (C-Term) Peptide (ABIN974737)
Target
CDC45L
(CDC45 Cell Division Cycle 45 (CDC45L))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CDC45L antibody (Catalog #: ARP51333_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CDC45L (CDC45 Cell Division Cycle 45 (CDC45L))
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Background
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CDC45L was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDC45, CDC45L2, PORC-PI-1, CDC45L
Protein Interaction Partner: CDK4,CDKN1A,CDKN2A,MCM10,MCM3,MCM7,ORC2L,ORC3L,ORC5L,POLA1,MCM3,MCM6,MCM7,ORC1L,ORC2L,ORC6L,POLA1
Protein Size: 566 -
Molecular Weight
- 65 kDa
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Gene ID
- 8318
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NCBI Accession
- NM_003504, NP_003495
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UniProt
- O75419
Target
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