Checkpoint Kinase 1 (CHEK1) Peptide
CHEK1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN974904
Quick Overview for Checkpoint Kinase 1 (CHEK1) Peptide (ABIN974904)
Target
CHEK1
(Checkpoint Kinase 1 (CHEK1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHEK1 antibody (Catalog #: ARP32589_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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Background
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CHEK1 is required during normal S phase to avoid aberrantly increased initiation of DNA replication, thereby protecting against DNA breakage. Its expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.
Alias Symbols: CHK1
Protein Interaction Partner: E2F1,E2F4,ATR,CDC25A,CDC25A,CDC25C,RAD51,RELA,AATF,AKT1,ATM,ATR,BLM,CDC25A,CDC25B,CDC25C,CLSPN,CSNK2B,CUL1,CUL4A,HSP90AA1,MDM4,RAD51,RELA,SMAD4,TLK1,TP53,UBB,XIAP,XRCC6,YWHAG,ATM,ATR,BLM,CDC25A,CDC25B,CDC25C,CDKN1A,CLSPN,CSNK2A1,MCD1,MSH2,PRKDC,SFN,TIMELESS,TP53,TP53BP1,XIAP,XRCC5,XRCC6
Protein Size: 476 -
Molecular Weight
- 54 kDa
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Gene ID
- 1111
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NCBI Accession
- NM_001274, NP_001265
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UniProt
- O14757
Target
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