Calsyntenin 1 (CLSTN1) (N-Term) Peptide
CLSTN1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975094
$160.46
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100 μg
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Quick Overview for Calsyntenin 1 (CLSTN1) (N-Term) Peptide (ABIN975094)
Target
Calsyntenin 1 (CLSTN1)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CLSTN1 Antibody(ARP44580_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Calsyntenin 1 (CLSTN1)
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Background
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CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
Alias Symbols: CSTN1, FLJ32258, KIAA0911, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CDHR12, ALC-ALPHA
Protein Interaction Partner: APBA2,APBB1,BAHCC1,CLSTN1,COL17A1,KIF2A,KLC1,KLC2,MCM3AP,PRNP,SETDB1,SLK,TOPBP1,TRIP12,APBA2,APP,PSEN1
Protein Size: 981 -
Molecular Weight
- 110 kDa
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Gene ID
- 22883
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NCBI Accession
- NM_001009566, NP_001009566
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UniProt
- O94985
Target
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