CAMP Responsive Element Modulator (CREM) Peptide
CREM
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975303
Quick Overview for CAMP Responsive Element Modulator (CREM) Peptide (ABIN975303)
Target
CREM
(CAMP Responsive Element Modulator (CREM))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CREM antibody (Catalog #: ARP34777_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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CAMP Responsive Element Modulator (CREM) peptide
CREM Reactivity: Human, Rat, Cow, Mouse Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CREM (CAMP Responsive Element Modulator (CREM))
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Background
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CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Alias Symbols: ICER, CREM-2, hCREM-2
Protein Interaction Partner: CDC34,CREB1,FHL5,KCNIP3,SPI1,TAF4,TBP,ATF1,CAMK2D,CAMK2G,CDC34,CDK1,CREB1,CREB3L1,CREBBP,CREM,CSNK1A1,CSNK2A1,CSNK2A2,FHL5,GSK3A,GSK3B,KCNIP3,PRKACA,PRKCA,SPI1,TAF4,TBP,CD34,FHL5,KCNIP3,SPI1,TAF4,TBP
Protein Size: 120 -
Molecular Weight
- 13 kDa
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Gene ID
- 1390
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NCBI Accession
- NM_182717, NP_874386
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UniProt
- O75519
Target
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